منابع مشابه
Chromatin Structure in Telomere Dynamics
The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence. In normal human somatic cells, characterized by telomere shortening with each cell division, telomere uncapping is...
متن کاملOrganization of DNA in chromatin ( chromatin structure / intercalation / DNA - kinking )
Conformational changes in DNA that accompany drug intercalation have led us to ask if DNA first bends or "kinks" to accept an intercalative drug or dye. Kinking is made possible by altering the normal C2' endo deoxyribose sugar ring puckering in B DNA to a mixed sugarpuckering pattern of the type C3' endo (3'-5') C2' endo and partially unstacking base-pairs. A kinking scheme such as this would ...
متن کاملChromatin structure and epigenetics.
In eukaryotic cells, the DNA molecule is found in the form of a nucleoprotein complex named chromatin. The basic unit of the chromatin is the nucleosome, which comprises 147 base pairs of DNA wrapped around an octamer of core histones (made of two molecules of each H2A, H2B, H3, and H4 histones). Each nucleosome is linked to the next by small segments of linker DNA. Most chromatin is further co...
متن کاملChromatin Structure and Function
In the best articles, generally those dealing with basic Chromosome Puffs research, the combination of depth and accessibility is impressive. One on Hox genes introduces the notion of The Science Times Book of Genetics a conserved body plan among species, illustrating the Edited by Nicholas Wade point with the fauna of Star Trek, and continues with New York: The Lyons Press (1999). 256 pp. an e...
متن کاملPlant Chromatin Structure
INTRODUCTION ..................................................................................... 235 NUCLEOSOMES IN HIGHER PLANTS ........................................................ 237 Microscopic Investigations ...................................................................... 237 Biochemical nd Biophysical Investigations ................................................. 237 CHROMA...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.5.3082